<International circulation>  : Are you aware of any promising methods to evaluate the microvasculor lesions?

Mieres:Yes.  In terms of microvasculor lesions， we know that MR sounds very promising.  Stress MR gives us some insight as to the microvasculature and subendocardial ischemia.  But in terms of
Microvasculor dysfunction， I know that PET perfusion imaging can give us an idea of a coronary reserve or abnormal floor reserve， and you can extrapolate that to be a dysfunction of the microvasculature.  So its MR， definitely; PET is promising; and I think maybe as CTA become more developed we might be able to see some profusion abnormalities with stress angiography.