Cardiac imaging has occupied a central place in cardiovascular diagnosis, ever since the beginning of the 20th century when standard roentgenography and fluoroscopy were applied clinically. Now we have the options for imaging the heart and adjacent structures, including echocardiography, cardiac computed tomography (CCT), myocardial perfusion imaging (MPI), cardiac magnetic resonance (CMR), positron emission or single-photon emission computed tomography, as well as invasive coronary angiography and left ventriculography. Over the past decades, many important advances have been made in each imaging modality. Cardiac imaging is now an integral part of the evaluation of patients with known or suspected heart disease, and is always included in clinical decision making. However, there are also confusion and misunderstanding among the subspecialists as well as the clinicians, even there are guidelines, recommendations or appropriateness published and refined. In addition, “cost-effect” is also an important issue to be considered. How do we use the current imaging modalities in our daily cardiology practice for the benefit of our patients? Please come and join the lecture.